Determining transition rates of ionic channels via observation 通过观测确定离子通道的转移速率
Transmembrane ionic channel currents were recorded by using the whole - cell patchclamp technique in single cardiac entricular myocyte enzymatically isolated from guinea - pig hearts 应用全细胞斑片钳技术记录酶学方法分离的豚鼠单个心室肌细胞离子通道电流。
Virtual myocardial cell describes electrophysiological detail such as the open and close of the ionic channel and ionic current with mathematical model 虚拟心肌细胞是用数学模型来描述了细胞兴奋过程中细胞膜各离子通道的开放、关闭及离子电流的活动等电生理细节。
Several patch clamp configurations have b een used to study the activity of ionic channels . the resting potential and capa citance as well as resistance of different lens cells were also measured 不仅记录了晶体细胞膜上多种通道活动,还测量了不同种属晶体上皮细胞的静息膜电位和膜电容,以及位于晶体内不同深度的晶体纤维细胞间的缝隙连接电阻。
For example , the application in protein folding in molecular biophysics , protein transport in cell biophysics , electrical neuron systems and ionic channel in neuron biophysics has become one of the important forward subjects hi international theory physics and biophysics 如在分子生物物理中的蛋白质折叠、细胞生物物理中的蛋白输运、神经生物物理中的电神经系统,离子通道等等方面的应用成为国际理论物理与生物物理学界研究的重要前沿课题之一。
In this paper , besides the simulation of the normal physiological condition , ecg waveforms under pathological conditions due to cell membrane ionic channel mutation such of as long - qt syndrome , short - qt syndrome , t wave alternans and brugada syndrome also be simulated and researched , which validated this ecg model , at the same time be beneficial to further research on 文中除了仿真正常生理状态下的心电图以外,对长qt间期综合症、短qt间期综合征、 t波电交替和brugada综合症等几种由细胞膜离子通道改变所引起的病态心电图波形也进行了仿真研究,充分验证了模型的正确性,同时也为进一步在此上进行疾病治疗药物的研究奠定了基础。